Heart Diseases and Stem Cell Transplantation

Heart Diseases and Stem Cell Transplantation Abstract According a report published by the World health organization about the most prevalent causes of mortality for the time periods of 2000 and 2011, it can be seen that Ischemic heart disease is the leading cause of mortality. There are many conditions that can lead to heart failure. Such conditions are raised blood pressure, myocardial infarction as well as atherosclerotic heart disease. Ischemia leads to necrosis of the myocardial cells due to lack of oxygen resulting in permanent loss of heart muscle. Stem cell therapy allows us to restore the motor function of the heart by delivering stem cells to the site of function loss. The aim of this review is to highlight key points about the different stem cell types that are being researched. Most importantly we will look at how and why recent advances are better suited for treatment of different conditions of the heart. This shall be argued by looking at the ways in which the stem cells used are obtained and transplanted as well as keeping in mind the natural behavior and purpose of the different classes of stem cells. Different Stem cell Types Being Researched The two classes of stem cells that have been researched the most are mulitpotent and pluirpotent stem cells. Pluripotent cells have a greater potency then multipotent stem cells meaning that only specific classes of multipotent stem cells can be used to restore cardiomyocytes. Multipotent Stem cells c-Kit+Cardiac Stem Cells These cardiac stem cells exhibit c-Kit+ which is a surface receptor that has tyrosine kinase activity. There have been successful studies using these types of cells for myocyte regeneration. According to Sheng and co-workers (2012) use of these stem cells has led to regeneration of cardiomyocytes in the ventricles. SCIPIO, is a phase 1 study conducted by Bolli et al. This study looked at patients who suffered from an MI and then had cardiac stem cells introduced into their left ventricle. They published their results in 2011 showing that left ventricular function improved from the initial ejection fraction that was below 40%. Makkar et al. in 2012 published findings for the CADUCEUS study. This study again introduced CSCs into patients LV just after an MI. Results showed no harm being done to the patient as well as an increase in the ejection fraction of the LV. Fuentes and Kearns-Jonker in 2013 released results were application of ephrin A1 can improve CSC treatment in rats. Ephrin A1 is a human protein important for moderating cell maturation that is introduced before transplantation of CSCs occurs. Most notably repopulation of the damaged area (infarct) was twice as much and as well as having improved systolic function as well as reduced number of complications such as arrhythmias. Bone marrow derived stem cells (BMSC) BMSCs are obtained from that patients bone marrow and then used to treat the same patient. BMSCs have been being used for a long time due to ease of acquirement as well as the fact that they don’t elicit an immune response when used. According to Sheng and co-workers (2012) BMSC therapy hasn’t lead to notable changes in patient quality of life with only temporary mild increase in ventricular systolic function. BMSCs release beneficial paracrine effects (Lee et al., 2005). Paracrines have a number of roles including cessation of apoptosis in sites of ischemic heart damage and stimulation of host vascular (angiogenesis) and cardiac tissue (cardiomyogenesis) growth. Inter-conversion of cells from 1 type to another as well as joining of 2 or more cells to become one cell results in formation of endothelial and ventricular muscle tissue from the precursor stem cell (Lee et al., 2005). Pluripotent stem cells Such cells are capable of forming all 3 primary layers. Embryo Stem cells (ESCs) ESCs are obtained from the mass of cells inside the blastocyst and are capable of self renewal. Compared to adult stem cells, embryonic stem cells have more inherent ability to replace damaged tissue in the heart. This is due to them being pluripotent they replace not only the muscle lost but also perform angiogenesis. Advancements in regulation of developmental pathways for ESCs have enabled improved results. BMP inhibitor improves the conversion of ESCs to cardiomyocytes but in so doing reduces conversion to other tissues of mesoderm origin (Hao et al., 2008). Hao and his co-workers (2008) also state that dorsomorphin can become a great tool for stem cell therapy in the future. Wnt/ÃŽ ²-catenin signaling control with the use of XAV939 improves ESC differentiation into cardiomyocytes. Induced pluripotent stem cells (iPS) Gene Transplantation Direct gene delivery For different forms of gene delivery the catheter has to both compatible to the site targeted as well as not having any property causing injury or eliciting an immune response. Naimark et al. compared the use of Nitinol stainless steel and Stiletto catheters for epicardial administration as well as endocardial showing that Stilletto catheters were twice as effective. Intrapericardial injection Advantage of this method of delivery is that there is no exposure of the heart and other organs. The use of intrapericardial infection in dogs has shown they endure the pain with not too much distress highlighting that the patient will undergo less distress compared to open surgery (March et al., 1999). This percutaneous method introduces the genes into the pericardial sac which then migrates into the myocardium. (Kawase et al., 2007) There are varying approaches to how to perform the injection. Fromes and coworkers used a transdiaphragmetic method. What was observed was that injection of the stem cells on their own lead to no gene expression difference in the myocardium. Stem cell expression results at the end of week one improved significantly with addition of proteinase in the injection fluid. Endocardial injection Microsphere retention varies according to volume used and site of injection. Endomyocardial injection had 28% greater retention then epicardial administration. Further retention can be obtained with the use of 10 ÃŽ ¼L rather then 100 ÃŽ ¼L. Greater spread of the adenovirus which encoded lac-Z was observed going to other organs in lower volumes too (Grossman et al., 2002). Use of fluoroscopy proved that this method is safe and that gene expression is present in 81% of the pigs used. Specimens used showed no symptoms and signs of cardiac arrhythmia or disturbance of blood flow. Patients suffering from chronic ischemia can develop complications such as perforation of the ventricle due to its thin nature as well as effusion of fluid in the pericardial sac decreasing cardiac output (Gwon et al., 2001). Intramyocardial injection This method has shown great success in many studies due to direct delivery of vector to site of damage. Injection of reporter gene into cardiac tissue and expression of the gene is feasible in canine myocardium. Response showed to be directly proportional to the volume of plasmid DNA used. Interestingly gene expression was uniform throughout the left ventricle independent of the level of injury. Stem cell expression gradually weakens over time showing greatest activity at the end of the first week (von Harsdorf et al., 1993). Use of plasmid DNA for cardiac muscle shows unique property of the tissue in being able to uptake DNA via the use of T tubules. Weakened expression after the first week is due to immune defensive mechanisms targeting transfected cells (Acsadi et al., 1991). Use of plasmid DNA vectors in early studies showed low efficiency in terms of transduction and time interval in which it is active; this lead to the use of adenovirus to transfer of ÃŽ ²-galactosidase gene an d plasmid. However results showed poor expression after day 7 as well as immune reaction generation (Guzman et al., 1993). Use of rAAV proved to be a more successful vector for the LacZ gene showing no immune response generation or inflammation at the site of injection. Expression was strongest after 1 week during weeks 4 to 8 showing very little results in the first 2 weeks. An increase in efficiency in terms of number of cells that undergo transduction due to perfusion was observed. Half of the cardiomyocytes showed LacZ gene expression (Svensson et al., 1999). BetaARKct gene produces a peptide that improves betaAR (beta-adrenergic receptor) signaling which is seen to diminish after a myocardial infarct. BetaAR function is interfered upon by G protein-coupled receptor kinase 2. BetaARKct gene product will eliminate G protein-coupled receptor kinase 2 interference. rAAV6 was used as a vector. Introduction of the BetaARKct gene further increased the efficiency of the intramyocardial injection with improved transduction cell number and length of time interval expression is strongest – up to 12 weeks from start of experiment. Long term use of BetaARKct gene lead to raised cardiac contractility as well as a turn around in ventricular remodeling (Rengo et al., 2009). Transfer of vascular endothelial growth factor (VEGF) promoted angiogenesis in damaged myocardium and diminished anginal pain (Koransky et al., 2002). Transvascular gene delivery Some diseases such as pulmonary and essential hypertension, long QT syndrome and congestive heart failure require not just a percentage of their cells to undergo transduction but rather the entire myocardium. This can only be done by a method that ensures global delivery to the myocardium (Donahue et al., 1997). This is because it’s not just a group of cells that are contributing to the disease but rather every cell. E.g. Intramyocardial injection in these conditions would be useless as it only affects a small area. Selective coronary catheterization with antegrade intracoronary delivery A single pass method yields poor transduction values showing phenotype expression in only 5% of cardiac muscle at most (Ding et al., 2004). For optimal transduction to take place prolonged exposure time via occlusion of blood supply was necessary. The coronary arteries and coronary venous sinus were the tested targets with the latter producing almost 5 times increase in transduction (Logeart et al., 2001). Donahue and coworkers worked on rabbit myocardium observing key conditions for 96% of myocardial cells to undergo transduction. These parameters included increased virus concentrations, increased exposure, performing experiment at 37 °C, increased coronary flow rate and use of crystalloid media with specific compositions. Almost maximal transduction could be achieved with improved microvascular permeability in a decreased coronary perfusion time period of 2 minutes. Lowered Ca2+concentration coupled to bradykinin or serotonin pretreatment and raised virus concentration achieve this (Donahue et al., 1998). Use of catheters to occlude the aorta and venous return in the right atrium in rodents was coupled to cardiopulmonary arrest with the use of esmolol and acetylcholine for 2 and 5 minutes in order to increase viral incubation time proved to increase transduction response in 43% of cardiac muscle after 3 days. Minimally invasive surgical intervention is still required but the fore mentioned method shows a 400 time improvement in phenotype expression contrasted to the sham-operated group. S-Nitroso-N-acetyl-DL-penicillamine and histamine use failed to improve microvacular permeability (Ding et al., 2004). Nonselective (indirect) intracoronary delivery Using a number of injections to transfer genes with the use of surgery has been studied in research extensively (Guzman et al., 1993). Transduction of human beta 2- adrenergic receptor (betaAR) gene in patients diagnosed with chronic heart failure can restore the cardiac beta-adrenergic receptor system. betaAR function is also compromised in acute myocardial function upset. The betaAR signaling pathway is the main target of most drugs on the market today for heart failure treatment (Parsa et al., 2003). Use of catheter to deliver Adeno-beta 2 adrenergic receptor into the left ventricle in rabbits produced at most a ten fold increase in beta 2- adrenergic receptor expression. After 3 weeks improved myocardial function was observed. Left ventricular pressure was improved as a result of increased myocardial contractility and improved ventricle loading conditions. Isoproterenol receptivity was also observed to increase (Maurice et al., 1999). This indirect method of virus introduction wi ll result in virus transport in the systemic circulation possibly resulting in ÃŽ ²-AR overexpression in the lungs and liver. Larger doses of the virus result in systemic ischemia and decreased cardiac function (Parsa et al., 2003). According to Hajjar and coworkers gene transfer in vivo results in transduction occurring in more then one location. In vivogene delivery involving adenovirus mediated transmission of betaAR kinase carboxyl terminus (betaARKct) or betaAR has shown that use of betaARKct prohibits smooth muscle hyperplasia in vascular intima after angioplasty. BetaARKct use improves ventrivular function via improved betaAR signaling via genetic inhibition of GÃŽ ²ÃŽ ³-ÃŽ ²-adrenergic receptor kinase. Over expression of betaAR improves cardiac function (Eckhart et al., 2000). Gene delivery in vivo improves ventricular contractility as well as adjustment of ECG intervals (Hajjar et al., 1998). Global phenotypic changes can be improved via increased transduction with the use of an improved method of to deliver the viruses. Introduction of the catheter into the left ventricular cavity followed by movement superiorly to end in the aortic root is coupled with pulmonary artery and ascending aorta occlusion. As a result a transcoronary perfusion gradient is generated; which improves viral delivery. This method has a number of modifications such as prompting of asystole pharmacologically, hypothermia use to lengthen cross-clamp interval and occlusion of the distal aorta (Beeri et al., 2002), (del Monte et al., 2001) and (Hajjar et al., 2000). Selective coronary sinus or coronary venous catheterization with retrograde delivery Intracoronary delivery involves systemic spread of the vector due to the brief interval in which the vector can adhere to the coronary endothelium. This is the great disadvantage of the fore mentioned method as coronary flow and endothelial permeability have a large contribution (Logeart et al., 2001). Contrasted to intracoronary delivery, retrograde delivery results in improved expression of the delivered gene (Kaye et al., 2007). Adeno-associated viral vectors do not induce an immune response and cause no inflammation. AAV vectors facilitate long-term gene expression (Sakata et al., 2007). Retro-infusion has proven to transfer AAV vectors efficiently as a long term method of gene transfer. This is due to improved endothelial permeability and lengthening of adhesion time for the vector (von Degenfeld et al., 2003). Systemic spread of vector to liver and lungs was observed however with lack of gene expression due to use of an enhanced myosin light chain promoter sequence (Raake et al ., 2008). Studies have proved that a single administration is enough in order for efficient regional myocyte transfection to occur. The advantages of only a single administration being necessary include minimal washout and controlled dwell times promoting longer exposure. The genes human developmentally regulated endothelial locus-1 and green fluorescent protein were used in this study (Hou et al., 2003). Pulmonary and hepatic transgene expression can be avoided with the use of adjusted models of myocardial gene delivery. Kaye and coworkers established a high efficiency percutaneous closed-loop system. This closed loop system permits increased transduction in the cardiac muscle due to higher concentration of vector present. This method reduces peripheral systemic spread that results in decreased transgene expression outside the heart in the lungs and liver (Kaye et al., 2007). Bridges states that usage of the percutaneous closed-loop system just mentioned would result in loss of more then 99% of the vector to the systemic circulation and not to the myocardium. On close examination of results obtained 2,639 vector genomes/ mg DNA were found in the heart contrasted to 69,595 vector genomes/ mg DNA in the liver. It was suggested that lack of hemiazaygous vein control results in this systemic spread. Ex vivotechnique Many studies have been carried out on the use of transplantation model for gene transfer. In the study done by Griscelli and coworkers recombinant adenoviruses are injected into coronary vessels of the organ then the heart is transplanted. This study carried out on piglet hearts have emphasized prolonged exposure time for vector contact to the heart. The advantage of using such a transplantation model is that this takes place with no coronary flow. Expression of transferred gene was noted with little presence of the transferred genome in hepatic and pulmonary tissues (Griscelli et al., 2003). Wang and Knechtle experimented on and compared 2 different methods of vector delivery prior to transplantation; myocardial injection and perfusion. Injection produced a higher degree of transgene expression. Perfusion resulted in greater overall distribution of transgene expression. Use of these methods only provides as a short term method of gene transfer (Wang and Knechtle., 1996).

indians :: essays research papers

the native american indians are very spiritula people. They hunt bison and buffalo In Indian Blood II, I incorrectly stated that Allan W. Eckert started "the Blue Jacket War."   He did not.   It seems clear now that Robert Van Trees did.   In fact, to call it a war is to mischaracterize this mindless tirade by Van Trees and some of his ardent supporters over a simple academic question:   Was Blue Jacket white?   Ã‚      Blue Jacket was a Shawnee chief and it is not really important  whether he was adopted or native--any more than it makes a difference whether one of his wives was white, which Van Trees does not dispute.   According to the information on Carlyle Hinshaw's website, Hinshaw called for a "crusade," using his word, to protest and suppress the republication of Eckert's The Frontiersmen. Thereafter, Eckert's publisher was bombarded with  letters and phone calls from the dozen or so people involved.   Letters were sent and some were posted on the site. Several people wrote Allan Eckert directly.   Ã‚      When asked for comment, Eckert said that some of the letters  he received in this "crusade" were actually hate mail, personally attacking him and calling him names. Pointless harassment.   I should point out that none of the responsible Shawnee scholars--neither Randy Noe nor John Sugden--would join in this disgraceful display of lynch-mob mentality.   Ã‚      I was given Hinshaw's web address by another Shawnee researcher.   Hinshaw's website   at first favorably impressed me, but after I came upon a page of protests led by Van Trees‘s article  entitled "Bluejacket and Swearingen Families Declare War on Eckert," I was taken aback. "Declare War," he says, in such strong language that makes you think of terroristic attacks, some kind of crazy holy war for, in his words, our "honored dead."   This strikes me as unfair and bizarrely un-American, like shouting down the opposition.   Ã‚     This is, after all, a simple and rather silly academic issue. If someone--Rev. Jesse Jackson, say--should write a book claiming that Blue Jacket was actually black and that historians had been wrong in their account of him all these years, would there be a similar protest?   I hardly think so.   Why not just write your own book and let the other fellow write his?   Ã‚     When I asked Mr. Van Trees about this, he said that the tirade against Eckert was justified and by US Mail he sent copies of the rabid hate mail that Robert Denton Bluejacket and others had sent  to Eckert--as if that explained everything.

Drug Addiction: And Urban Social Problem Essay

There are several concurrent urban social problems and for many years now authorities of a community have huge difficulties in eradicating these socially damaging situations. The issue of drug addiction has always been common and widespread in our society. For some reasons this worldwide predicament is very difficult to expunge thus, creating a humungous problem of our world. This shaped several individuals’ lives when the addiction to illegal substances sets in and likewise affected the future of the communities they belonged to especially their children, who of course look up to their parents for guidance. This began a long time ago but the problem is not diminishing and instead became progressively prevalent where teenagers nowadays are provided easy access to these deadly drugs by drug peddlers or pushers on the streets. Drug pushers have even become innovative on ways to introduce these life destructing substances to children just for them to earn easy money the fastest possible way. Some kids get introduced to these illegal substances without being aware what they have gotten into. Those born on the years from 1946 to 1964, were called Baby Boomers and were also exposed to drugs that significantly marked a different era in history. Mike Males, who is a teacher in UC Santa Cruz, and also a baby boomer, raised some criticisms on his own generation. He said that they are the fastest growing age group for felony arrests in California that has the biggest demographic for HIV and AIDs cases and has a one in three ratio of obese people. Since 75. 8 million Americans belong to this generation, their views and the actions dominate the society. They are in the media, fill the church pews, run the corporations thus ruling the market and sat on the Oval office (Hubler). Mike Males even described their generation as; Its members became wildly well-educated and turned â€Å"sex-drugs-and-rock-and-roll† into a mass motto. Then they left all that behind to form a lot of blended, two-income, exceptionally health-conscious households. Then they became inordinately conscientious parents, rethinking whole aspects of child-rearing, but in a good way. Now they’re safely ensconced in midlife and expecting to live past 100, with no worries save for the ever higher cost of seeing the Rolling Stones. (Hubler) His story has even been confirmed by government statistics and other scholars story in saying that, †Ã¢â‚¬ ¦ problems among teens are declining but problems among their baby boom parents were another matter† (Hubler). Having a population dominated by the baby boomers may have its effects to the existence of some urban problems that are still hounding our communities. It was with great dependence on their action that their kids will be able to survive as well as the future generations. However, this generation as parents, have also nurtured their children by providing the support that they needed and wanted (Value Options). They also did wjat they could to provide their children a better and content future. They were also good parents to their kids. We cannot generalize an age group belonging to different society but still the fact remains that the drug problem is still predominant in the society. On the other hand, the children of the baby boomers are referred to as the Generation Y, who are those people born from years 1980 to 1994. They are also called Echo Boomers, Millennial Generation and Generation Next. This new generation is now coming of age to work and transform the future of the humankind. The Echo Boomers are very much controlled by technological innovations that have emerged in the latest years. They have â€Å"The Baby Boomers saw the future as theirs and Generation Xers found the future disheartening, these young workers question whether they will have a future. They have spent a good deal of time watching as their parents rose to the top of the corporate ladder, balancing work and family, and they have seen their parents lose jobs as a result of downsizing and reorganizations. For this generation, work is temporary and unreliable. They are less committed to an employer, sensing that employers are less committed to long-term employment. In some respect, this group is opportunistic and will job hop to meet their immediate wants, needs and goals† (Value Options). Apparently, in some cases, this has caused some adolescents to develop some psychological ordeal full of uncertainties in what the future holds for them that some resort to alcoholism, depression, smoking and drug addiction at a young age. Some of these people gets involve in something due to curiosity and experimentation. Without the parents’ strong presence in their lives, they just may be led on the wrong path. So many events has happened during their time such as high school, college school and even mall shooting as well as the 9/11 attacks. With all these things happening, more support is needed by these people to overcome some trauma. For those who cannot get the support and guidance that they need from their elders, they turn to drugs to momentarily forget their fears, anger and insecurities especially for teenagers. Addiction results from the relationship between a person and the object of their addiction (Schaffer). The sources of drug addiction are the actual drugs that people take, of which some are prescribed for a certain illness or not. Most of these drugs cannot be faced out in the market since it is also very beneficial to the lives of those afflicted by some deadly or threatening diseases. The only way to do for these substances to be safe or away from drug abusive individuals is the control that is implemented by the government to every area. It is a responsibility that should be taken seriously by the ones in governmental positions or in power. Also a huge support from families, friends and community to those people especially the adolescents should be formed to give them the guidance they need. Many of these groups are existent today and are already causing remarkable changes in the lives of some young ones. Drugs would always be in the streets since people would still keep making them for a good or bad cause but we have to focus on what really pushes people to turn to drugs. If we go down to the root of the issue, we would know what to do to be able to stop this worsening predicament. If people’s interests in illegal substances are eliminated, then there will be no consumers for these individuals producing and selling these drugs. No one will be selling something of which no one is buying. If it is parental support that is lacking, everyone should do their best to become responsible parents and give the support their kids deserve. This boils down to family relationships since this is primarily where kids are guided to straighten out their lives and erase the confusions that bother them most which then results to having these vices. It is not fair to pinpoint on whether it is the fault of the Baby Boomers or the Generation Y that this social problem is still rampant. Both generations passed through their adolescent stages where people become vulnerable to such addictions. Everyone knows how confusing it is when we were on this phase and so we know how they should be guided and reared to become responsible and good citizens of this country. The drug problem is there because all of us need to pool our resources together and put more force in bringing this drug problem down. It is not just a responsibility of one generation or one country. It is a problem that can only be solved if every one of us would help each other and take it as our own responsibility to make this world a safe haven for the following generations. WORKS CITED Hubler, Shawn. â€Å"The Boomer Buster – Who is Mike Males, and why is he saying those awful things about people of a certain age? † 22 January 2006. Center on Juvenile and Criminal Justice Press Room. 9 December 2007 . Schaffer, Howard J. â€Å"What is an Addiction: A Perspective. † 3 July 2007. Harvard Medical School Division on Addictions. 9 December 2007 . â€Å"Generation Y†. Value Options. 9 December 2007. .

Chemistry and Element Jokes and Puns

You dont hear a lot of jokes, puns, or riddles in physics and biology, but chemistry is full of them. Here is a collection of reader-submitted chemistry jokes and puns. Some of them are groaners, but some are quite funny. You can read other jokes specific to certain topics, like Mole Day. Two guys walk into a restaurant. One guy says I would like some H2O. The other guy says I would like some H2O too (H2O2). The waiter delivers the drinks and the second guy dies after imbibing his. (H2O is water, while H2O2 is hydrogen peroxide.) I told a chemistry joke... There was no reaction.Why are helium, curium, and barium the three main medical elements? If you cant curium or helium, you barium!Are you  hydrogen? Why? Because I cant live without you.Are you 11 protons? Cause you are sodium fine.What did the chemist say to motivate his team? We ARGON to BARIUM.What dont you understand about copper? It makes perfect CENTS!A good way to remember gold is Au gimme that gold.What do you do with a dead scientist? You barium. Thats if you cant helium or curium.A wrestler holding down an opponent may have a NEON him.Two chemists walk into a bar, the first says I will have some H2O and the second one says I will have some H2O too and the second one dies! Hahaha (get it... H2O2 is hydrogen peroxide and you cant drink it or you will die)What happened to the chemist in the cave - Berkelium (bear kill him)Hey want to hear a joke about potassium?... KYou must be ethidium bromide, because Im tangled in your double helix.Are you made out of beryllium, ununtrium, and titanium ? Cause youre a BeUTi ( beauty)Do particles with multiple helium isotopes have mass? Only the Catholic ones!Are you feeling under the weather today? Because you look like youre Na fine.Sooo I was gonna tell you a joke about sodium and hydrogen......but NaH.So an atom walks into a bar with a gun and the bartender says Who are you and what do you want? to which the atom replies The names Bond, Ionic Bond, and I want an electron taken, not shared.What do you do to dead elements? You barium.I was looking for sodium on the periodic table, but then it told me it was not available!  (Na)What do you say when: oxygen, hydrogen, sulfur, sodium and phosphorous walk into a bar? OH SNaP!Knock Knock, Whos There? Beryl.  Beryl who?  Beryl and LiumAre you made of fluorine, iodine, and neon? Because youre so fine! F is fluorine, I is iodine, and Ne is the element symbol for neon.What did the chemist do when he cut his leg? He put his neon (knee on) a table to bandage it up.Chemistry jokes are sodium funny! Hah... say it out loud.sodium sodium sodium sodium sodium sodium sodium sodium BATMAN!Argon walks into a bar. Bar man says, We dont serve noble gases. Argon doesnt react. (Noble gases are unreactive.)I am a superhero Fe Iron Male man Therefore I am iron man.What is the elements favorite carnival ride? The Ferrous Wheel, of course!Forget hydrogen youre my number one element.When someone I dont like asks me to hang out I tell them sodium hydrogen. (NaH)Did you hear Oxygen and Potassium went on a date? Yeah, it went OK. (O is the symbol for oxygen, while K is the symbol for potassium.)Did you hear that Oxygen and Magnesium hooked up last night? OMgAre you a mixture of Fluoride, Iodine, and Nitrogen cause you are fine.You wanna hear a joke about potassium?.......K ?  You wanna hear a joke about sodium?.......Na You wanna hear a joke about silicon?........Si  You wanna hear a joke about nitrogen and oxygen?.......NO You wanna h ear a joke about tungsten?........WTeacher: Do you know your elements? Student: yeah, maybe... Teacher: isotope so.Are you made of copper and tellurium Because youre pretty CuTe!Q: Why does helium laugh so much? A: Because it goes HeHe (Which is actually a pretty poor joke because helium is monatomic.)Chemist 1: do you have any sodium bromate? Chemist 2: NaBrOWhat does a metal miner write home in a letter to his girlfriend? I am zincing of you all the time!What does Uranium, Nickel, Cobalt, and Radon spell? UNiCoRn!Guys, stop it with the puns. Weve all sulfured enough.My jokes are kinda boron.. but a lot of the good ones argon. Id pay a nickel to hear another joke. These are comedy gold.I was going to tell a periodic table joke but all them argon.They were standing in their yards. Pop the Cd In neighbor!Come on guys, these chemistry jokes are getting a bit boron.Q: What did the chemist say when he found two isotopes of Helium? A: HeHeWhat do you say when someone takes your gold watc h? Au come back with my watch!What did the elements say to hydrogen? What a loner!Billy was a chemists son but now he is no more. What he thought was H2O was H2SO4!Q: What did one ion say to another? A: Ive got my ion you.My dog died so I had to barium.Protons have mass? I didnt know they were Catholic?Youre so boron Im going to go find a krypton to barium in.A neutron went to buy a drink. He asked the employee how much it is. Employee: For you, no charge! Proton 1: Hey, that man just got a free drink! Proton 2: Are you sure? Proton 1: Im positive!Obama is giving his speech. Joe Wilson says: U Li!!This joke is sodium good. (You have to hear it to get it.)How did the boss speak to the very lazy employee? Fermium, of course!What do you get when you mix helium with steel? flying carsA teacher asks their class what the molecular formula for water is. A student replies HijklmnO. The teacher says no youre wrong. Then the student says didnt you say the formula was H to OAll the elements ar e sitting at the dinner table and neon says Helium dont eat too much! Youre gonna get fat! Helium says No Im not, Im the second lightest here!First person: Do I have a joke on sodium Answer: NaWhat element did the dinosaurs say killed them? ArgonJoke: what does the chemist tell his friends when he goes into an eatery? When I go into a restaurant, iodine.What is uranium fluorine oxygen? Answer: UFOWe should just find all the bad chemistry jokes and just barium.Teacher: Whats the molecular formula of water? Student: HIJKLMNO Teacher: No, thats wrong. Student: But didnt you say water is H to O?Carbon was saying to oxygen hey did you hear about the new phone company O2? And then oxygen said yeah they named it after me. HAHAHAHAHelium walks into a store and asks for his nickel but the manager said, Your brother? Get it? They are both on the periodic table!1st Person: Do you like Iron man, coz I do! 2nd Person: No, he just a big Fe Male!What is a house cats favorite chemical compound? MoUSeI would tell you a good element joke, but they ARGON!!!What do you call iron blowing in the breeze? FebreezeSilicon jokes: Q: Is silicon the same in Spanish? | A: SiQ.Why do chems call Helium, Curium and Barium, phenetical elements? A. coz if you cant Helium or Curium, YOU BARIUMPerson 1: Does anyone know any good jokes about sodium? Person 2: Na  Anyone know any sodium, bromine, or Oxygen jokes? Na BrOChemistry jokes are sodium funny. Hahahahahaahaha  Argon walks into a bar, the bartender says We dont serve nobles gasses here. Argon doesnt react.Lets head on down to the cemetery and get our Krypton.Ii would say a good chem joke but all the good ones ARGONDid you hear? Oxygen and magnesium got together OMg!!Why did the scientist want carbon, Arsenic, and Hydrogen? It makes CAsHSo some helium walks into the bar and says lets Barium!!! everyone screamed. why are you screaming? Asked helium  Cause you want to bury um!!A man walks into a bar and asks for H2O then a 2nd man co mes in and asks for H2O too. The second man died. (The 2nd man asked for H2O2, which is liquid poison.)A neutron walks into a bar and says How much for a beer? The barman says For you NO CHARGE  Q: If H2O is the formula for ice, what is the formula for ice? A: H2O cubed.These element jokes are so dead, we should barium.Hydrogen and Oxygen walk into a bar and see Gold... they say Au, get outta the bar!Q: What did the copper say to the steel-er? A: CesiumWhat does a good doctor do for his patients? --HeliumWhats the best formula for breakfast? Barium, Cobalt, and Nitrogen (BaCoN)What did the bar-tender say when Oxygen, Hydrogen, Sulfur, Sodium, and Phosphorus walked into his bar? OH SNaP!What song starts with Oxygen Hydrogen Sodium Sodium? Oh Na Na, whats my name.A proton and a neutron are walking down the street. The proton says, Wait, I dropped an electron help me look for it. The neutron says Are you sure? The proton replies Im positive.So one guy says to another Wanna hear a pot assium joke? KWhat did two scientists do when their test subject died? BariumWhat animal do you get when you take out the T, A and I in the word Potassium. Possum.If Fe is Iron, then does that mean that a Female is Iron Man?Sodium Bromate Joke: Want some sodium bromate? Na BrO!I would tell you a chemistry joke but all the good ones Argon!Want me to tell a potassium joke? K.... Will you accept a sodium joke? Na, im fineI dont want to tell jokes in class because I might get NO REACTIONWhat do tomb robbers do to pyramids? -Radium What did the king say to the guard when the prisoner escaped? -Cesium!Susan was in chemistry. Susan is no more, for what she thought was H2O was H2SO4How did Arsenals become a strong club in English premier league? Because they are bronzed with Arsenic.What will happen if you get into water and cant zwim? Zinc!What sharp object do you get when you combine potassium, nickel, and iron? -- KNiFeCarbon! - The happy Frenchmans opinion after buying his new automobil e.When my wealthy old aunt passed away I got all the antimony!Whats the name of the element that comes after nine? -- TinWhats the first thing a teenager does after school? -- Radon food in the fridgeWhat did the cowboy do with his horse? -- Rhodium Where did he do it? -- Holmium on the RangeWhat do you do with a dead chemist? Barium. (Explanation: bury em, bury them sounds like barium)Zinc Element Joke: Where do you put dirty dishes? In the zinc.